Food and Environmental Forum 2020

Chromicent is pleased to present our method for the detection of pyrrolizidine alkaloids by LC-MS/MS and SFC-MS/MS developed by our project manager Maike Rehn at the Food and Environmental Forum 2020.

Save the Date: 05. und 06. Mai 2020

Abstract

Insights into method development for the determination of pyrrolizidine alkaloids – UPLC vs. UPC2

Pyrrolizidine alkaloids are phytochemicals, some of which have liver-toxic, carcinogenic and mutagenic effects. The two complementary chromatography techniques – Liquid Chromatography and Supercritical Fluid Chromatography – were compared for the development of a method for the determination of 28 of these harmful compounds from herbal medicines and teas.

Food and Environmental Forum

The Food and Environmental Forum is part of Waters’ #AnalyticalFoodies initiative.

The intention of the initiative is to provide support in all areas of food analysis, always in compliance with guidelines and regulatory requirements.

You can find an overview *here*

Pyrrolizidine alkaloids

Pyrrolizidine alkaloids (PA) are secondary metabolites that are formed by various plant species to repel predators. PA can cause life-threatening liver disease and are considered likely to be carcinogenic, therefore they present a significant risk potential in food and feed.

In addition to bee products (honey, pollen), the main focus of current analysis is on medicinal and herbal teas (including rooibos tea, black and green teas).

To date, there are no legal limits for PA, but the Federal Institute for Risk Assessment (BfR) recommends that consumers’ overall exposure be kept as low as possible. According to the risk assessment, a daily intake of 0.007 µg PA/kg body weight should not be exceeded.

As a result of consumers’ increased attention to natural medicine and healthy, conscious nutrition, the demand for medicinal and herbal teas is rising. Therefore, pyrrolizidine alkaloids present a current issue, especially in the field of teas for infants and toddlers. If you would like to know more about this topic or would like support with the analysis, please contact us.